Detox-N-Cleanse

Detox-N-Cleanse is a 100% vegan Food supplement. Detox-N-Cleanse is a synergistic blend of foods and food extracts intended to help support healthy colon, urinary, metal, and other detoxification. Pollution can be a serious issue [1], so many naturally-minded individuals are justifiably concerned about detoxification.

The outside air is polluted, the indoor air is polluted, water is polluted, and the industrialized food supply is polluted with toxins. There are vehicle exhausts, industrial gases, industrial chemicals, chlorinated-fluoridated-plasticized tap water, molds, pesticides, herbicides, preservatives, radiation, colorings, perfumes, colognes, medications, printer/copier dusts, paints, carpet out-gassing, cleaning supplies, and a host of other pollutants. Even toys are still found containing toxic chemicals (and even those that have supposedly “safe” materials, like plastic, can still outgas).

Detoxification from toxins makes a great deal of sense in this chemically-altered modern world.

“The etiology of many neurodegenerative diseases has been only partly attributed to acquired traits, suggesting environmental factors may also contribute. Metal dyshomeostasis causes or has been implicated in many neurodegenerative diseases” [2]. Some believe that heavy metals also predispose people to candidiasis/systemic mycoses and/or intestinal issues [3-4].

Other Ingredients: Vegetarian (HPMC) Capsule.
Suggested use: Serving size or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

Acerola Cherry is one of the most vitamin C dense Foods [5]. Not only does it have free radical scavenging abilities, it also has been shown to increase the antioxidant abilities of some other foods [6]. “Acerola…contains bioflavonoids” [6], anthocynins, and quercitin [7]. One study concluded that vitamin C “supplementation provides a protective effect against exercise-induced airway narrowing in asthmatic subjects” [8]. Vitamin C has been used to help detoxify from aluminum, arsenic, cadmium, lead, mercury, nickel, and more [9]. Acerola cherries also contain soluble and insoluble fiber, and such fibers are often part of successful colon cleanses.

Apple Pectin has been shown to support and improve colon health [10-13], and it also provides fiber [13]. Apple pectin exerts “a scavenger effect in the intestinal digestion and portal circulation system as an anti-inflammatory food” [13]. Apple pectin has been successfully given as a radioprotection agent to reduce radiation levels in those affected by Chernobyl [14-15]. It has long been used for those with dyspepsia and other digestive complaints [9].

Bioflavonoids are found in acerola cherry, cilantro, collinsonia, garlic, wheat grass, and other plants [16]. Bioflavonoids, such as Quercitin dihydrate have long been used for toxicities. Even the PDR admits that quercitin may “have benefit in some allergic conditions, in conditions characterized by capillary fragility, in chronic prostates and in some cancers…Quercetin is one of several flavonoids that have effects on mast cells and basophils…it might be useful in some allergies, such as hay fever. Quercetin can help prevent the release of histamine and other mediators of allergies, possibly stabilize cell membranes so that they are less reactive to allergens” [5]. “The major active biological constituents in Citrus herbs are flavonoids, especially hesperidin, naringin and alkaloids, mainly synephrine, with beneficial medical effects on human health” [17]. Quercetin is often advised for those with asthma, allergic rhinitis, or hay fever [18]. Bioflavonoids are also sometimes simply called flavonoids. Citrus bioflavonoids have been found to have anti-allergic effects and may be useful to improve symptoms associated with seasonal allergic rhinitis [19].

Chlorella is a special type of algae. Chlorella is often used for heavy metal and other forms of detoxification. It has the ability to absorb mercury, cadmium, arsenic and other heavy metals [9]. The PDR states, “Chlorella…contains chlorophyll, car otenoids, such as astaxanthin, canthaxanthin, flavoxanthin, loraxanthin, neoxanthin, and violaxanthin. Chlorella also contains the xantho phyll, echinenone…Chlorella has putative anticarinogenic, immunomodulatory, hypolipidemic, gastric mucosal-protective and detoxification activities…In rats, chlorella was found to promote the excretion of dioxin…Chlorella had demonstrated ability to protect against gamma-radiation, as well as a number of drugs and various toxic chemicals” [5]. Live chlorella has been found to remove lead from waste water [20].

Chlorophyll is contained in chlorella, cilantro, and wheat grass. Chlorophyll has been used to help detoxify from fluoride and as well as toxic substances [5,9]. It “may ameliorate some drug side effects” [5]. Chlorophyll is often a component of successful colon detox programs.

Cilantro Coriandrum sativum is also known as Chinese parsley. It has been found to accelerate the excretion of lead and mercury through urine [21]. It has also been found to remove both inorganic and methyl forms of mercury [22]. Another study concluded that cilantro “has suppressive activity on lead deposition, probably resulting from the chelation of lead by some substances contained in Chinese parsley” [23].

Collinsonia Root is also called stone root and has tonic effects, which may be due to its essential oil and rosmaric acid [16]. It contains a relatively unique bioflavonoid 2,5-dihydroxy-dimethoxyflavone, along with the flavones “baicalein-6,7-dimethyl ether (2), norwogenin-7,8-dimethyl ether (3), and tectochrysin (5-hydroxy-7-methoxyflavone)” [24]. It is most often used for stomach complaints, hemorrhoids, or constipation [25,26], while its tonic effects within the bowels help maintain a state of calm (and also helps the bowels function more naturally). It is “[o]f reputed value in Varicose Vein conditions and for Hemorrhoids” [27]. It has long been used in combination with ox bile to help support bile flow and deal with indigestion [28]. Collinsonia root “is used for calculi, kidney stones, urea (bladder semolina), bladder inflammation, dropsy and gastrointestinal disorders” [29].

Garlic has been used to help detoxify from aluminum, arsenic, beryllium, lead, mercury, and nickel [9]. “Garlic is used internally as an adjuvant to dietetic measures for elevated lipid levels. The herb is also used for prevention of age-related vascular changes and arteriosclerosis”. “Garlic contains compounds that help prevent nitrites—common substances found in foods as well as a variety of every day pollutants—from transforming themselves into nitrosamines, harmful compounds that can trigger cancerous changes in the body” [8]. Garlic has anti-oxidant effects which means it can reduce toxicity associated free-radical damage. “Garlic contains the trace elements germanium and selenium, which have been thought to play a role in improving host immunity and ‘normalizing’ the oxygen utilization in neoplastic cells” [18]. Garlic compounds have been found to inhibit lipid peroxidation, which “is considered to be one of the main features of aging in liver cells” [18].

Modified Citrus Pectin (from inner citrus peel) is one of the most effective known natural detoxifiers. It has been found to be effective for many heavy metals [30]. A urinary output study found that it can reduce toxic metals like lead and cadmium in people with supposed “normal” levels of those toxins [31]. Additionally, has reduced lead in children with toxic lead levels [32]. It has been claimed that, “Even though modified citrus pectin is strong enough to soak up toxins and heavy metals in your system like a sponge, it is also gentle on your system. Not a single person in these human trials reported any side effects. Modified citrus pectin is one of the safer forms of toxin removal because it does NOT deplete essential minerals your body needs. So while it eliminates toxic metals and pesticides like lead, cadmium, and mercury, it doesn’t deplete your body of zinc, calcium, or magnesium” [33]. Pectin has been used to help detoxify from mercury and nickel [9]. “Heavy metals like mercury, lead, cadmium and arsenic have been implicated in a wide number of health problems, including arteriosclerosis, hypertension, multiple sclerosis, impaired immune function, and an overgrowth of Candida albicans. Research exists showing the effectiveness of pectin in chelating (binding to) heavy metals and removing them from the body” [3]. It has been studied for prostate issues “for further chemopreventive and chemotherapeutic analysis in vivo”[34].

Slippery Elm is an herb long used for successful colon cleansing. “The main focus of Slippery Elm is the GI Tract where it can provide nutrition, a soothing coat over stomach and intestinal ulcers, soothing the colon…and to absorb foul gases [35]. “Slippery elm contains large amounts of mucilage, which will coat the surface of the mucous membranes or surface of wounds and sores when it comes in contact with water…Slippery elm has been successfully used as a demulcent and emollient” [16]. “It has also been known to ‘draw out’ toxins, boils, splinters, and other irritants” [36]. Historically, it has been used “in the treatment of gastritis and gastric or duodenal ulcers” [16]. Some believe slippery elm is “effective for protection against stomach ulcers, colitis, diverticulitis, gut inflammation, and acidity. Slippery elm is also useful for diarrhea, constipation, hemorrhoids, irritable bowel syndrome, and to expel tapeworms” [36].

Wheat Grass Triticum aestivum is a highly akalizing Food [37]. It has long been used to re-invigorate health, and for other complaints of fatigue [38]. Wheat grass is rich in chlorophyll [5]. Wheat grass has been used to help detoxify from fluoride and as well as other toxic substances [5,9]. “Wheat grass is used as a general health tonic and… a…beneficial role of wheat grass in ameliorating hyperlipidemia and the associated oxidative stress” [39]. It may help with certain types of IBS (irritable bowel syndrome) [5,40].

CNN reported about a small American study recently found 232 unnatural chemicals in the umbilical cords of newborn human infants [41]. We are living in an age where there are too many chemicals and other toxins in the environment.

Detox-N-Cleanse contains natural vitamin C from acerola cherries (and no isolated ascorbic acid), herbs, and other plant extracts that support healthy detoxification. It is the choice for natural health professionals interested in 100% Food detoxification.

Detox-N-Cleanse Video

References

[1] Tecer LH, Alagha O, Karaca F, Tuncel G, Eldes N. Particulate Matter (PM(2.5), PM(10-2.5), and PM(10)) and Children's Hospital Admissions for Asthma and Respiratory Diseases: A Bidirectional Case-Crossover Study. J Toxicol Environ Health A. 2008;71(8):512-20
[2] Yokel RA. Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration. J Alzheimers Dis. 2006 Nov;10(2-3):223-53
[3] Fuchs N. The amazing health benefits of modified citrus pectin. New Living Magazine, October 2003
[4] Thiel, R. Systemic mycoses: An overview for natural health professionals. The Original Internist, 14:2, June 2007:57-66
[5] Sheldon SH, Rorvik D, eds. PDR for Nutritional Supplements. Medical Economics, Montvale (NJ), 2001
[6] Hwang J, Hodis HN, Sevanian A. Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract. J Agric Food Chem. 2001;49(1):308-314
[7] Hanamura T, Mayama C, Aoki H, Hirayama Y, Shimizu M. Antihyperglycemic effect of polyphenols from Acerola (Malpighia emarginata DC.) fruit. Biosci Biotechnol Biochem. 2006 Aug;70(8):1813-20
[8] Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM. Ascorbic acid supplementation attenuates exercise-induced bronchoconstriction in patients with asthma. Respir Med. 2007 Aug;101(8):1770-8
[9] Thiel R. Serious Nutrition for Health Care Professionals, 3rd ed. Center for Natural Health Research, Arroyo Grande (CA), 1997
[10] Shinohara K, Ohashi Y, Kawasumi K, Terada A, Fujisawa T. Effect of apple intake on fecal microbiota and metabolites in humans. Anaerobe. 2010 Mar 19. [Epub ahead of print]
[11] Licht TR, Hansen M, Bergström A, Poulsen M, Krath BN, Markowski J, Dragsted LO, Wilcks A. Effects of apples and specific apple components on the cecal environment of conventional rats: role of apple pectin. BMC Microbiol. 2010 Jan 20;10:13
[12] Liu L, Li Y, Niu Y, Sun Y, Guo Z, Li Q, Li C, Feng J, Cao S, Mei Q. An Apple Oligogalactan Prevents against Inflammation and Carcinogenesis by Targeting LPS/TLR4/NF-{kappa}B Pathway in A Mouse Model of Colitis-Associated Colon Cancer. Carcinogenesis. 2010 Apr 16. [Epub ahead of print]
[13] Tazawa K, Yatuzuka K, Yatuzuka M, Koike J, Ohkami H, Saito T, Ohnishi Y, Saito M. [Dietary fiber inhibits the incidence of hepatic metastasis with the anti-oxidant activity and portal scavenging functions] [Article in Japanese]. Hum Cell. 1999 Dec;12(4):189-96
[14] Nesterenko VB, Nesterenko AV. Decorporation of Chernobyl radionuclides. Ann N Y Acad Sci. 2009 Nov;1181:303-10
[15] Bandazhevskaya GS, Nesterenko VB, Babenko VI, Yerkovich TV, Bandazhevsky YI. Relationship between caesium (137Cs) load, cardiovascular symptoms, and source of food in 'Chernobyl' children -- preliminary observations after intake of oral apple pectin. Swiss Med Wkly. 2004 Dec 18;134(49-50):725-9
[16] Gruenwald J, Brendler T, Jaenicke C, editors. PDR for Herbal Medicines, 4th ed. Thomson, Montvale (NJ), 2007
[17] Ding L, Luo X, Tang F, Yuan J, Liu Q, Yao S. Simultaneous determination of flavonoid and alkaloid compounds in Citrus herbs by high-performance liquid chromatography-photodiode array detection-electrospray mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Oct 1;857(2):202-9
[18] Balch JF, Balch PA. Prescription for Nutritional Healing. Avery Publishing, Garden City (NY), 1997
[19] Tanabe S, Kinuta Y, Yasumatsu H, Takayanagi M, Kobayashi S, Takido N, Sugiyama M. Effects of Citrus unshiu Powder on the Cytokine Balance in Peripheral Blood Mononuclear Cells of Patients with Seasonal Allergic Rhinitis to Pollen. Biosci. Biotechnol. Biochem. 2207, 71 (11), 2852–2855
[20] Mohapatra DK, Mohanty L, Mohanty RC, Mohapatra PK. Biotoxicity of mercury to Chlorella vulgaris as influenced by amino acids. Acta Biol Hung. 1997;48(4):497-504
[21] Omura Y, Beckman SL. Role of mercury (Hg) in resistant infections & effective treatment of Chlamydia trachomatis and Herpes family viral infections (and potential treatment for cancer) by removing localized Hg deposits with Chinese parsley and delivering effective antibiotics using various drug uptake enhancement methods. Acupunct Electrother Res. 1995 Aug-Dec;20(3-4):195-229
[22] Karunasagar D, Krishna MV, Rao SV, Arunachalam J. Removal and preconcentration of inorganic and methyl mercury from aqueous media using a sorbent prepared from the plant Coriandrum sativum. J Hazard Mater. 2005 Feb 14;118(1-3):133-9
[23] Aga M, Iwaki K, Ueda Y, Ushio S, Masaki N, Fukuda S, Kimoto T, Ikeda M, Kurimoto M. Preventive effect of Coriandrum sativum (Chinese parsley) on localized lead deposition in ICR mice. J Ethnopharmacol. 2001 Oct;77(2-3):203-8
[24] Stevens JF, Ivancic M, Deinzer ML, Wollenweber E. A novel 2-hydroxyflavanone from collinsonia Canadensis. J Nat Prod. 1999 Feb;62(2):392-4
[25] Cotran RS, Kumar V, Collins T. Robbins Pathologoical Basis for Disease, 6th ed. WB Saunders, Phil, 1999
[26] Scalzo R. Naturopathic Handbook of Herbal Formulas, 3rd ed. Kivaki Press, Durango (CO), 1994
[27] Lee R. Collinsonia. In Product Bulletins, circa 1950
[28] Lee R. Cholacol. In Product Bulletins, circa 1950
[29] Gruenwald J, Brendler T, Jaenicke C, eds. PDR for Herbal Medicine, 2nd ed. Medical Economics, Montvale (NJ), 2000
[30] Eliaz I, Weil E, Wilk B. Integrative medicine and the role of modified citrus pectin/alginates in heavy metal chelation and detoxification--five case reports. Forsch Komplementmed. 2007 Dec;14(6):358-64
[31] Eliaz I, Hotchkiss AT, Fishman ML, Rode D. The effect of modified citrus pectin on urinary excretion of toxic elements. Phytother Res. 2006 Oct;20(10):859-64
[32] Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, Eliaz I. The role of modified citrus pectin as an effective chelator of lead in children hospitalized with toxic lead levels. Altern Ther Health Med. 2008 Jul-Aug;14(4):34-8
[33] Sears A. 6-day citrus detox. Doctor’s House Call, June 28, 2010
[34] Yan J, Katz A. PectaSol-C modified citrus pectin induces apoptosis and inhibition of proliferation in human and mouse androgen-dependent and- independent prostate cancer cells. Integr Cancer Ther. 2010 Jun;9(2):197-203
[35] Ritchason J. The Little Herb Encyclopedia, 3rd ed. Woodland Health Books, Pleasant Grove (UT), 1995
[36] Burnham TH, et al, editors. The Review of Natural Products. Facts and Comparisons, St. Louis. 2001
[37] Null G. The Complete Encyclopedia of Natural Healing. Kensington Books, NY, 1998
[38] Duke J.A. The Green Pharmacy. Rodale Press, Emmaus (PA), 1997
[39] Sethi J, Yadav M, Dahiya K, Sood S, Singh V, Bhattacharya SB. Antioxidant effect of Triticum aestivium (wheat grass) in high-fat diet-induced oxidative stress in rabbits. Methods Find Exp Clin Pharmacol. 2010 May;32(4):233-5
[40] Langmead L, Rampton DS. Review article: complementary and alternative therapies for inflammatory bowel disease. Aliment Pharmacol Ther. 2006 Feb 1;23(3):341-9
[41] Gupta S. Toxic Childhood. CNN, August 7, 2010

Some of these studies (or citations) may not conform to peer review standards (though most do). Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.