Chromium GTF
90 Tablets $20.98
Vegetarian Formula * Dietary Supplement

Doctors understand that, “The biologically active form of chromium, sometimes called glucose tolerance factor or GTF, has been proposed to be a complex of chromium, nicotinic acid, and possibly the amino acids glycine, cysteine, and glutamic acid. Many attempts have been made to isolate or synthesize the glucose tolerance factor; none have been successful” [1]. Food Chromium GTF, however, naturally contains this glucose tolerance factor chromium. Chromium is not naturally found in the body in the commonly supplemented forms such as chromium picolinate or chromium chelate. Only 1% or less of inorganic chromium is absorbed vs. 10-25% of chromium GTF [2]. Research suggests that there is much less likelihood of toxicity from chromium in foods than from chromium picolinate, chromium chelate or chromium VI [3].

Chromium has been reported to reduce sugar cravings [4] and is sometimes advised to help with weight loss. There is an exceedingly small amount of chromium in white sugar, but that small amount can cause cravings if the body is otherwise deficient in chromium. However, since some chromium is needed by the body to fully digest white sugar, this sometimes leads to a cycle of repeated sugar cravings. Supplemental chromium can help break this sugar craving cycle.

Chromium is found in Food with accompanying Food factors which include protein chaperones [5,6]. which aid in absorption of chromium (chromium mineral salts are chemical compounds which are rocks or synthetically produced). Chromium rocks are poorly absorbed by humans (some are less than 1% absorbed [2]). Plants convert soil constituents including chromium into Food [7]. Humans are supposed to consume Food, not soil [7]. Yet most chromium-containing supplements do not contain chromium as found in Foods; instead they contain various acid-processed rocks or other mineral salts. Consuming mineral salts poses at least two problems. The first is that the body has to attempt to breakdown the rock into its elemental forms, which it is not really designed to do (plants are supposed to do that [7], which is why they are considered to be lower down on the food chain than humans). The second is that the body has to discard the non-chromium portion somehow as it may not be of any use to the body (if undesirable elements accumulate, they can contribute to toxic accumulations and/or reactions in the body, including free radicals). Because it is a Food and not ground up rock, 100% Food Chromium GTF is easier on the digestive system than other chromium supplements and can often be better tolerated by sensitive individuals.

What Kind of Chromium is in Your Chromium Supplements?

Chromium Form Actually Is / Often Used As
   
Chromium chloride A preparation of hexahydrates; used as a corrosion inhibitor & to waterproof [8].
Chromium picolinate Chromium III with picolinic acid; picolinic acid is used in herbicides [9].
Food Chromium GTF Enzymatically processed plants; only used as a food.

Please also understand that chromium picolinate is a human-made substance, apparently created by Gary Evans [8,10]--it is not a natural food. Picolinic acid is used in herbicides [9]; furthermore “picolinic acid is an excretory or waste product. It is not metabolized by, or useful to the body” [11]. Scientists report, “some research groups recently suggested that chromium (III) picolinate produces significantly more oxidative stress and potential DNA damage than other chromium supplements” [3].

Chromium, Saccharomyces Cerevisiae, and Diabetes

“Chromium is generally accepted as an essential nutrient that potentiates insulin action, and thus influences carbohydrate, lipid, and protein metabolism” [1]. One small study found that Food Chromium GTF reduced blood glucose levels by 16.8% versus 6.0% for inorganic chromium [12], thus it was 2.80 times more effective. Another study found that Food Chromium GTF benefited certain diabetics by improving blood glucose control, lowering serum lipids, and decreasing the risk of coronary heart disease [13].

Saccharomyces cerevisiae is also known as nutritional or baker’s yeast and it holds several unique advantages for diabetics. Perhaps the first is that it is the most natural medium in which to grow Food Chromium GTF. GTF is the body’s form of chromium (Cr) and is the form that is best for regulating blood sugar. Specifically it has been found that “dietary high Cr yeast supplementation improved glucose tolerance, probably through a decrease in hepatic extraction of insulin” [12]. Saccharomyces cerevisiae chromium GTF is up to 25 times more bioavailable than chromium mineral salts [2].In 1999, the Nobel prize was awarded for discovering that protein chaperones are necessary for mineral transport into cellular receptors; Saccharomyces cerevisiae naturally contains protein chaperones and other Food factors which aid in mineral absorption [5,6] (these are lacking in chromium salts).

Additionally, Saccharomyces cerevisiae has proinsulin-like substances, “the specificity of the yeast processing enzymes is so similar to the proinsulin converting enzymes in the human pancreatic beta-cell that it allows the processing of the mini-proinsulin to insulin” [13]. Saccharomyces cerevisiae also contains a variety of insulin precursors that can be helpful for diabetics [14].

Saccharomyces cerevisiae (the primary yeast used in baking and brewing) is beneficial to humans and can help combat various infections [15], including Candida albicans according to the German E monograph. In the text, Medical Mycology John Rippon (Ph.D., Mycology, University of Chicago) wrote, “There are over 500 known species of yeast, all distinctly different. And although the so-called ‘bad yeasts’ do exist, the controversy in the natural foods industry regarding yeast related to health problems which is causing many health-conscious people to eliminate all yeast products from their diet is ridiculous.” It should also be noted, that W. Crook, M.D., who was perhaps the nation’s best known expert on Candida albicans, wrote “yeasty foods don’t encourage candida growth...Eating a yeast-containing food does not make candida organisms multiply” [16]. Some people, however, are allergic to the cell-wall of yeast [18] and the Saccharomyces cerevisiae in all Food Research products have had the cell-wall enzymatically processed to reduce even this unlikely occurrence. It should also be noted that nutritional yeast is NOT the same as brewer’s yeast which is essentially a waste by-product.

Other Nutrients

Food Chromium GTF naturally also contains vitamins B-1, B-2, B-6, Niacinamide (B-3), Folate (B-9), and Pantothenate (B-5); it also contains phosphorus, potassium, and a variety of trace minerals (kelp and dulse are excellent Food sources of trace minerals). B vitamins are involved in the productions of energy as well as other metabolic processes [17]. B complex vitamins, potassium, and trace minerals are often recommended for diabetics; particularly for the prevention and reversal of oxidative-dysoxygenative insulin dysfunction [18]. Hypophosphatemia (low phosphorus levels) is clinically associated with diabetes mellitus [17]; “Excessive amounts of phosphorus can also be lost in the urine of uncontrolled diabetics who have polyuria and acidosis” even if plasma phosphorus appears to be normal [17].

100% Food Chromium GTF naturally contains superoxide dismutase (S.O.D.). S.O.D. “is one of the most important enzymes that functions as a cellular antioxidant...The absence of this enzyme is lethal” [17].

Since Food Chromium GTF is so much better than other forms, why would anyone want to take something else?

Supplement Facts
Serving Size 1 tablet
Servings per container 90

Amount per serving RDI
Thiamin (B-1) (in 537 mg food) 14 mcg *
Riboflavin (B-2) (in 537 mg food) 2 mcg *
Niacinamide (in 537 mg food) 177 mcg *
Vitamin B-6 (in 537 mg food) 20 mcg *
Folate (in 537 mg food) 0 mcg *
Pantothenate (in 537 mg food) 39 mcg *
Magnesium (in 622 mg food) 3.0 mg *
Chromium, GTF (in 54 mg food) 100 mcg 83%
Phosphorus (in 622 mg food) 8.0 mg *
Potassium (in 622 mg food) 7 mg *
Dulse Plant Rhodymenia palmatta 40 mg **
Kelp Thallus Ascophyllum nodesum 45 mg **
Rice Bran Oryza sativa 500 mg **

* Contains less than 2% of RDI
** Recommended Daily Intake has not been established.
Other ingredients: Lecithin, Vegetable Lubricant, Silica, Food Glaze, Guar Gum.

Contains naturally occurring carbohydrates, lipids, proteins (including all ten essential amino acids), superoxide dismutase, and truly organic bioflavonoids as found in enzymatically processed Saccharomyces cervisiae, Rice bran Oryza sativa, Mixed vegetable fiber Cellula vegetabalis, Kelp thallus Ascophyllum nodesum, Dulse plant Rhodymenia palmatta, and Buckwheat rutin Fagopyrum esculentum --all the nutrients shown above are contained in these foods. Unlike many so-called “natural” chromium formulas, this Chromium GTF is a food chromium (not a mineral salt) contains no synthetic USP nutrients or mineral salts, but only contains foods, food complexes, and food concentrates.

Numerous university studies have concluded that supplements containing food nutrients are better than USP isolates. Food nutrients are better because they contain important enzymes, peptides, and phytonutrients CRITICAL to the UTILIZATION of vitamins and minerals which are not present in isolated USP nutrients. Published research has concluded that food vitamins are superior synthetic/USP vitamins.

Suggested use: 1-3 tablets per day or as recommended by your health care professional. Adjust usage according to nutritional lifestyle requirements.

References

[1] Nielson F. Chromium. In Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil.,1994:264-268

[2] Ensminger AH, Ensminger ME, Konlade JE, Robson JRK. Food & Nutrition Encyclopedia, 2nd ed. CRC Press, New York, 1993

[3] Stoecker B.J. Chromium. In Modern Nutrition in Health and Disease, 10 th ed. Lippincott Williams & Wilkins, Phil., 2005: 332-337

[4] Thiel RJ. Serious Nutrition for Health Care Professionals, 2nd ed. Center for Natural Health Research, Arroyo Grande (CA), 1986

[5] Rouhi AM. Escorting metal ions: protein chaperone protects, guides, copper ions in transit. Chem Eng News, 1999;11:34-35

[6] Himelblau E, et al. Identification of a functional homolog of the yeast copper homeostasis gene ATX1 from Arabidopsis. Plant Physiol 1998;117(4):1227-1234

[7] Cronquist A. Plantae. In Synopsis and Classification of Living Organisms, Vol. 1. McGraw-Hill, 1982:57

[8] Budavari S, et al. The Merck Index, 12th ed. Merck & Co., Whitehouse Station (NJ), 1996

[9] DiTomaso JM. Yellow starthistle: chemical control. Proceedings of the CalEPPC Symposium, 1996, as updated 5/2/02

[10] Chromium picolinate, rev. 6/96B.BLI website, July 16, 2002

[11] Implications of the ‘other half’ of a mineral compound. Albion Research Notes 2000;9(3):1-5

[12] Guan X, Matte JJ, Ku PK, Snow JL, Burton JL, Trottier NL. High chromium yeast supplementation improves glucose tolerance in pigs by decreasing hepatic extraction of insulin. J Nutr 2000;130(5):1274-1279

[13] Thim L, Hansen MT, Sorensen AR. Secretion of human insulin by a transformed yeast cell. FEBS Letters 1987, 212(2):307-312

[14] Kjeldsen T. Yeast secretory expression of insulin precursors. Appl Microbiol Biotechmol 2000;54(3):277-286

[15] Gruenwald et al editors. PDR for Herbal Medicines, 2nd ed. Medical Economics Company. Montvale (NJ) 2000

[16] Crook W. The Yeast Connection: A Medical Breakthrough. Professional Books, Jackson, TN; 1986

[17] Shils ME, Olson JA, Shike M. Modern Nutrition in Health and Disease, 8th ed. Lea & Febiger, Phil; 1994

[18] Ali M. Beyond insulin resistance and syndrome X: The oxidative-dysoxygenative insulin dysfunction (ODID) model - Part III. Townsend Letter for Doctors & Patient 2002;232:114-118

Some of these studies (or citations) may not conform to peer review standards, therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.